Increased pressure in the portal vein may lead to the development of large, swollen veins within the esophagus, stomach or rectum. The veins can rupture and bleed, resulting in potentially life-threatening complications.
The most common cause of portal hypertension is cirrhosis of the liver. In cirrhosis, the scar tissue blocks the flow of blood through the liver.
In some cases, patients with portal hypertension can develop accumulation of fluid in the abdomen known as ascites. Ascites can sometimes be managed by changes to diet and use of medications. However, sometimes patients with ascites and cirrhosis can develop hepatorenal syndrome, a type of progressive kidney failure seen in people with severe liver damage, most often caused by cirrhosis. As the kidneys stop functioning, toxins begin to build up in the body. Eventually, this leads to liver failure.